Hyperbaric Oxygen Treatment in Autism Spectrum Disorders
Title: Hyperbaric Oxygen Treatment in Autism Spectrum Disorders
Publisher: Medical Gas Research (Print: 2012/2: 16) (Online: 06/15/2012)
Note: Review of different studies with visual representations of improvements.
Pressure: 1.3 ATA & 1.5 ATA
Oxygen Concentration: Various (typically 24% – 100%)
Duration: Various (typically 40 – 60 min)
Sessions: Various (typically 20 – 40)
Conclusion: HBOT at the pressures commonly used in children with ASD (up to 1.5 atm/100% oxygen) has been reported to improve cerebral perfusion, decrease markers of inflammation and not worsen oxidative stress markers. Most studies of HBOT in children with ASD reported improvements in several behavioral domains although many of these studies were not controlled. Although the two trials employing a control group reported conflicting results, a recent systematic review noted several important distinctions between these trials. Collectively, the reviewed studies indicate that the use of HBOT in children with ASD is associated with minimal adverse events and is well tolerated. We conclude that HBOT is a safe and potentially effective treatment for children with ASD but that further studies are warranted.
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Hyperbaric Treatment for Children with Autism: a Multicenter, Randomized, Double-blind, Controlled Trial
Title: Hyperbaric Treatment for Children with Autism: a Multicenter, Randomized, Double-blind, Controlled Trial
Publisher: BioMed Central (Online: 03/13/2009)
Pressure: 1.3 ATA
Oxygen Concentration: 24%
Duration: 60 min
Sessions: 40
Conclusion: Children with autism who received hyperbaric treatment at 1.3 atm and 24% oxygen for 40 hourly sessions had significant improvements in overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to children who received slightly pressurized room air.
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The Effects of Hyperbaric Oxygen Therapy on Oxidative Stress, Inflammation, and Symptoms in Children with Autism: an Open-label Pilot Study
Title: The Effects of Hyperbaric Oxygen Therapy on Oxidative Stress, Inflammation, and Symptoms in Children with Autism: an Open-label Pilot Study
Publisher: BioMed Central Pediatrics (Print: 2007/7: 36) (Online: 11/16/2007)
Pressure: 1.3 ATA & 1.5 ATA
Oxygen Concentration: 24% – 100%
Duration: 45 min
Sessions: 40
Conclusion: In this prospective pilot study of children with autism, HBOT at a maximum pressure of 1.5 atm with up to 100% oxygen was safe and well tolerated. HBOT did not appreciably worsen oxidative stress and significantly decreased inflammation as measured by CRP levels. Parental observations support anecdotal accounts of improvement in several domains of autism. However, since this was an open-label study, definitive statements regarding the efficacy of HBOT for the treatment of individuals with autism must await results from double-blind, controlled trials.
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Hyperbaric Oxygen Therapy in Thai Autistic Children
Title: Hyperbaric Oxygen Therapy in Thai Autistic Children
Publisher: Journal of the Medical Association of Thailand (Print: 2008 Aug; 91(8): 1232-8)
Pressure: 1.3 ATA
Oxygen Concentration: 21% (ambient air) [assumed]
Duration: unknown
Sessions: 10
Results: Improvement was shown in five domains with a significant level. Seventy-five percent of children shown improvement while 25% did not seem to respond to the treatment.
Conclusion: HBOT is a new treatment for Thai autistic children. Many scientific studies recently have shown that HBOT could be an effective treatment for autistic children. It could improve the major autistic symptoms.
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