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Wound Healing

mHBOT Studies & Research

Hyperbaric air mobilizes stem cells in humans; a new perspective on the hormetic dose curve

Keywords: Stem Cells

Title: Hyperbaric air mobilizes stem cells in humans; a new perspective on the hormetic dose curve

Publisher: Frontiers in Neurology (Volume 14 – 2023 | published on 06/20/2023)

Pressure: 1.27 ATA

Oxygen Concentration: 21% (ambient air)

Duration: 90 min

Sessions: 10

Results: SPCs (CD45dim/CD34+/CD133) were mobilized by nearly two-fold following 9 exposures (p = 0.02) increasing to three-fold 72-h post completion of the final (10th) exposure (p = 0.008) confirming durability.

Discussion: This research demonstrates that SPCs are mobilized, and cytokines are modulated by hyperbaric air. HBA likely is a therapeutic treatment. Previously published research using HBA placebos should be re-evaluated to reflect a dose treatment finding rather than finding a placebo effect. Our findings of SPC mobilization by HBA support further investigation into hyperbaric air as a pharmaceutical/therapy.

Conclusion and Impact: In this study we demonstrate for the first time that intermittent exposure to ostensibly insignificant pressures of hyperbaric air mobilizes stem progenitor cells in a similar manner to that seen in isobaric hyperoxia and hyperbaric oxygen therapy. We also establish that the stem progenitor cell mobilization is durable.

This research reveals that hyperbaric air, even at an ostensibly insignificant dose, has significant effects on human physiology, is not a placebo, and should be considered as an active physiologic intervention. Its use as a pharmaceutical should be investigated further.

Although this study did not test for clinical results, clinical outcomes of hyperbaric air have been reported in similar hyperbaric air studies. This study supports the data, but refutes the conclusions in those studies by revealing a mechanism of action for the clinical improvements reported in the hyperbaric air group in those studies. Much more work is needed to develop protocols of hyperbaric air dose that provide the maximum therapeutic benefit.

These findings substantiate the need for testing hyperbaric air doses prior to using hyperbaric air as a placebo in scientific investigations. These findings also substantiate the urgent need for reevaluation of findings in historical studies using hyperbaric air placebos. Our findings suggest that these historical placebo-controlled studies were not placebo-controlled studies. Paradoxically, our findings indicate that they were dose studies and the findings of a “placebo effect” or “participation effect” are inherently flawed. The “findings” and “conclusions” in studies using hyperbaric air as a placebo should be reevaluated from a dose study perspective. Finally, we hope the findings in this study will persuade the medical societies around the world to consider reevaluation of their definition of hyperbaric medicine to include nominal hyperbaric air.

Looking back at the “Hyperbaric Air” work of Henshaw, Simpson and Cunningham, our findings support their reports.

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Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells

Keywords: Inflammation

Title: Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells

Publisher: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc (Print: 2013 Mar-Apr;40(2):115-23) (Online: 03/2013)

Pressure: 1.5 ATA & 2.4 ATA

Oxygen Concentration: 96.7% & 97.9%

Duration: 90 min

Sessions: 1

Discussion Excerpt: Our study demonstrates a significant effect of PO2 on mRNA expression of genes involved in angiogenesis (VEGFB, ANGPT2 and CTGF) with the greatest reduction being seen at 1.5 atm abs when compared to the chronic wound model conditions.

Interestingly, oxygen at 1.5 atm abs affected many genes much more strongly than oxygen at 2.4. The reasons for this effect are unknown, but it does raise questions about the most appropriate treatment pressures for inflammatory conditions. As well as different facilities differing in their treatment protocols for the same conditions, different conditions are treated with different treatment pressures, and more research is needed to investigate the most appropriate treatment pressures for individual conditions. The benefit of reduced risks of oxygen toxicity when treating with oxygen at lower pressures have long been recognized, and rather than treating patients according to convention, there are important advantages to be gained by performing more studies to monitor wound healing under different treatment pressures.

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Effect of hyperbaric oxygen therapy on the healing of postoperative wounds in bitches after hemimastectomy

Keywords: Mastectomy, Surgery

Title: Effect of hyperbaric oxygen therapy on the healing of postoperative wounds in bitches after hemimastectomy

Publisher: Polish Journal of Veterinary Sciences (Print: Vol. 23, No. 4, 2020, 495–499) (Online: 12/2020)

Pressure: 1.5 ATA

Oxygen Concentration: 26%

Duration: 90 min

Sessions: 5

Conclusion: It should be stated that, based on the results of the present study, the use of L-HBOT does have a positive effect on the treatment of postoperative wounds.

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